A DWF is like an electronic plot. It takes the settings from your layouts, as intended for a piece of paper, and captures all of that data in the DWF file. An uninitialized layout means that you need to make sure your layouts have valid plotter settings. You may never have any intention of plotting from AutoCAD, using DWF exclusively instead, but the DWF file will be constructed so that it looks like what the layout would have looked like if it had been plotted to a device. A layout that is not initialized is often a layout in an AutoCAD drawing that has not been accessed when the drawing was created. For example, when creating a new DWG, there is the Model, Layout 1, and Layout 2 tabs. If you draw in the Model and in Layout 1, but never access Layout 2, then Layout 2 is not initialized. Once you work with Layout 2, it will be initialized. So please ensure that all layouts have complete and desirable plotter settings before creating your DWF files. An alternative is to delete unwanted layouts or deselect them from the DWF publishing process.